Methods for preventing and treating tissue injury and sepsis...

Details Methods for preventing and treating tissue injury and sepsis... Methods for preventing and treating tissue injury and sepsis...

A - Human Necessities

61

K

A61K 31/522 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2638448

Methods for treating and preventing tissue injury and sepsis associated with a Yersinia pestis infection, particularly pneumonic plague, are provided. The methods of the invention comprise administering to a subject a therapeutically effective amount of an A1 adenosine receptor antagonist alone or in combination with at least one additional therapeutic agent, including an antibiotic agent. The present methods find use in biodefense as a means of preventing and treating tissue injury and sepsis associated with Y. pestis infection, particularly pneumonic plague, in the event of a bioterrorist attack with this deadly bacterium.

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