Methods for preventing crystal growth and particle...

Details Methods for preventing crystal growth and particle... Methods for preventing crystal growth and particle...

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 9/14 (2006.01)

Patent

CA 2367096

The present invention is directed to methods for preventing crystal growth and particle aggregation in nanoparticulate compositions. The methods comprise reducing a nanoparticulate composition to an optimal effective average particle size. The resultant nanoparticulate compositions exhibit prolonged particle size stability and minimal crystal growth, even following exposure to elevated temperatures.

La présente invention concerne des procédés de prévention de la croissance de cristaux et de l'agrégation particulaire dans des compositions nanoparticulaires. Les procédés consistent à réduire une composition nanoparticulaire à une taille particulaire moyenne efficace optimale. Les compositions nanoparticulaires obtenues présentent une stabilité prolongée de la grosseur des particules et une croissance minimale des cristaux, même après exposition à des températures élevées.

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