Methods for preventing degradation of protein c

Details Methods for preventing degradation of protein c Methods for preventing degradation of protein c

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 38/48 (2006.01) A61K 47/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2139468

The present invention relates to methods to prevent or minimize autodegradation of activated protein C. The invention is best exemplified by performing the processing, purification and/or storage of the activated protein C at low pH, for example at about pH 6.3 to about pH 6.5. Autodegradation of aPC may also be minimized by incubating the aPC in 3 M urea (complete recovery of aPC activity is obtained after the removal of the denaturant) or by incubating the aPC in the presence of extreme salt concentrations. The present invention also comprises aPC formulations which maintain the aPC at low pH, in denaturant, or at extreme salt concentrations.

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