A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) C07K 14/52 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2360672
A method for inhibiting the rejection of transplanted grafts is disclosed. The method comprising administering an effective amount of an antagonist of CCR1 function to a graft recipient. Also disclosed is a method of inhibiting ischemia/reperfusion injury comprising administering to a subject in need thereof an effective amount of an antagonist of CCR1 function. The disclosed methods can also comprise the co-administration of one or more additional therapeutic agents, for example, immunosuppressive agents and cell adhesion inhibitors.
L'invention se rapporte à une méthode d'inhibition du rejet des greffes. Ladite méthode consiste à administrer une quantité efficace d'un antagoniste de la fonction CCR1 à un receveur de greffe. L'invention se rapporte également à une méthode d'inhibition des lésions résultant d'une ischémie/reperfusion et consistant à administrer à un sujet nécessitant un tel traitement une quantité efficace d'un antagoniste de la fonction CCR1. Les méthodes de l'invention peuvent également comporter la co-administration d'un ou de plusieurs agents thérapeutiques, par exemple des agents immunosuppresseurs et des inhibiteurs d'adhésion cellulaire.
Millennium Pharmaceuticals Inc.
Ogilvy Renault
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