Methods for preventing neural tissue damage and for the...

Details Methods for preventing neural tissue damage and for the... Methods for preventing neural tissue damage and for the...

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/00 (2006.01) G01N 33/20 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2415179

The present invention provides methods of determining aggregation of a- synuclein, which are a hallmark of Lewy body diseases such as Parkinson's disease. Also disclosed are inhibitors of the aggregation, including magnesium and a-synuclein binding peptides. The inhibitors are useful in the treatment of Lewy body diseases.

L'invention concerne des procédés qui permettent de déterminer l'accumulation d'alpha-synucléine, caractérisant les maladies à corps de Lewy du type maladie de Parkinson. L'invention concerne également des inhibiteurs de ladite accumulation, y compris le magnésium et les peptides se liant avec l'alpha-synucléine. Ce genre d'inhibiteur est utile pour le traitement des maladies à corps de Lewy.

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