Methods for preventing or treating infectious diseases...

A - Human Necessities – 61 – K

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A61K 33/24 (2006.01) A61K 31/4164 (2006.01) A61K 31/43 (2006.01) A61K 31/4439 (2006.01) A61K 31/5377 (2006.01) A61K 31/555 (2006.01) A61K 31/7042 (2006.01) A61P 1/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2682745

The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a patient a compound containing gallium. The extracellular microorganisms targeted by the present methods include methicillin- resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), E. coli O157:H7, fluoroquinolone-resistant Salmonella typhi, and the like. Furthermore, in the present methods, gallium compounds can be co-administered with one or more conventional antimicrobial agents to treat infectious diseases with reduced risks of creating multi-drug resistant pathogens. The methods of the present invention is also applicable to those microorganisms, such as ulcer-causing Helicobacter pylori, complete eradication of which so far has been difficult to achieve.

La présente invention concerne des procédés destinés à la prévention ou au traitement de maladies infectieuses causées par des micro-organismes extracellulaires, tels que des bactéries et champignons, par une administration systémique à un patient d'un composé contenant du gallium. Les micro-organismes extracellulaires ciblés par les présents procédés incluent Staphylococcus aureus résistant à la méthicilline (MRSA), Enterococccus faecalis résistant à la vancomycine (VRE), E. coli O157:H7, Salmonella typhi résistante à la fluoroquinolone, et analogues. En outre, dans les présents procédés, des composés de gallium peuvent être administrés concomitamment avec un ou plusieurs agents antimicrobiens classiques pour traiter des maladies infectieuses avec des risques réduits de créer des pathogènes résistants à de multiples médicaments. Les procédés de la présente invention sont également applicables à des micro-organismes tels que Helicobacter pylori qui est responsable d'ulcères, dont l'éradication complète a été difficile à obtenir jusqu'à présent.

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