A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/28 (2006.01) A61K 31/166 (2006.01) A61K 31/425 (2006.01) A61K 31/4468 (2006.01) A61K 31/454 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61K 31/64 (2006.01) A61K 31/7048 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2406947
Disclosed are methods for preventing or treating a gastrointestinal (GI) disorder in a mammal such as a human patient. In one embodiment, the methods include administering to the mammal a therapeutically effective amount of a compound that modulates a nitric oxide (NO) signaling pathway, particularly in GI neurons. Methods of the invention are particularly useful for the treatment (including prophylactic treatment) of diabetic gastropathies and other GI disorders.
La présente invention concerne des procédés qui permettent de prévenir et de traiter un trouble gastro-intestinal (GI) chez un mammifère tel qu'un patient humain. Dans une forme de réalisation, les procédés consistent à administrer au mammifère une quantité thérapeutiquement efficace d'un composé qui module une voie de signalisation de l'oxyde nitrique (NO), notamment dans les neurones GI. Les procédés selon l'invention sont particulièrement utiles pour le traitement (y compris le traitement prophylactique) des gastropathies diabétiques et d'autres troubles gastro-intestinaux.
Ferris Christopher D.
Snyder Solomon H.
Watkins Crystal C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Johns Hopkins University
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