A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/02 (2006.01)
Patent
CA 2635480
A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and undergoes chemical fixation. The fixed tissue is then immersed in a series of fresh bioburden reduction process (BRP) solutions to extract phospholipids. The tissue procurement solution reduces the bioburden on the stored tissue and preserves tissue architecture by minimizing tissue swelling. The tissue procurement solution further reduces calcium from the incoming water and/or tissue, and inhibits enzymes that digest the collagen matrix. The serial immersion of the tissue in the fresh bioburden solutions ensures optimal extraction of phospholipids thereby mitigating subsequent calcification of the tissue.
L'invention concerne un procédé pour traiter un tissu biologique utilisé dans des prothèses biologiques, qui consiste à fournir une solution de formation de tissu, formée à partir d'une solution tampon saline phosphate (PBS) et d'un agent chélateur. Le tissu est transféré depuis la solution de formation de tissu et subit une fixation chimique. Elle est ensuite immergée dans une série de solutions de processus de réduction de charge microbienne (BRP) à des fins d'extraction de phospholipides. La solution de formation de tissu réduit la charge microbienne sur le tissu stocké et préserve l'architecture du tissu par la minimisation du gonflement du tissu. La solution de formation de tissu réduit également le calcium de l'eau entrante et/ou du tissu et inhibe les enzymes qui digèrent la matrice de collagène. L'immersion en série du tissu dans des solutions fraîches de charge biologique assure une extraction optimale de phospholipides et atténue ainsi la calcification subséquente du tissu.
Cambron Ronald E.
Cunanan Crystal M.
Ochoa Alexandro
Arbor Surgical Technologies Inc.
Smart & Biggar
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