Methods for producing acylphenylalanine

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 231/02 (2006.01) C07C 233/63 (2006.01) C07D 213/82 (2006.01) C07C 233/47 (2006.01) C07C 233/49 (2006.01) C07C 233/51 (2006.01) C07C 233/87 (2006.01) C07C 235/60 (2006.01)

Patent

CA 2425533

There is provided a method for producing acylphenylalanine that is useful as a raw material of pharmaceutical products which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under alkali condition by using potassium hydroxide.

L'invention concerne un procédé permettant de préparer facilement et simplement des acylphéylalanines de grande pureté extrêmement utiles comme matière première pour des médicaments ou pour des articles analogues. Ce procédé se caractérise par la réaction d'un chlorure d'acide avec de la phénylalanine dans un solvant mixte composé d'un solvant inorganique et d'eau, dans un environnement maintenu alcalin avec de l'hydroxyde de potassium.

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