C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C12N 5/0781 (2010.01) C07K 16/10 (2006.01) C07K 16/12 (2006.01)
Patent
CA 2740138
The invention relates to methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen. The invention also relates to antibodies and antibody fragments produced by the methods of the invention as well as methods of using the antibodies and antibody fragments.
La présente invention concerne des procédés de production danticorps, comprenant des anticorps monoclonaux, comprenant la culture dun nombre limité de plasmocytes. Elle concerne en outre des procédés didentification danticorps en effectuant des essais sur les anticorps produits par les plasmocytes cultivés pour déterminer leurs fonction, spécificité de liaison, spécificité dépitope et/ou leur capacité à neutraliser une toxine ou un pathogène. Linvention concerne en outre des anticorps et des fragments danticorps produits par les procédés de linvention ainsi que des procédés dutilisation des anticorps et fragments danticorps.
Jarrossay David
Lanzavecchia Antonio
Institute For Research In Biomedicine
Mbm Intellectual Property Law Llp
LandOfFree
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