C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/78 (2006.01) C07K 16/40 (2006.01) C12N 15/55 (2006.01) C12P 7/40 (2006.01) C12P 7/42 (2006.01) C12P 13/04 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2365224
(57) Abstract: In accordance with the present invention there are provided methods for producing enantio merically pure .alpha.-sustituted carboxylic acids, such as, for example, .alpha.-amino acids and .alpha.- hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypepdde having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cynohydtin intermediate under conditions sufficient to produce the carboxylic acid.
La présente invention concerne des méthodes destinées à la production d'acides carboxyliques alpha -substitués énantiomériquement purs tels que des alpha -aminoacides et des acides alpha -hydroxy, ladite méthode consistant à combiner un aldéhyde ou une cétone avec un cyanure et un ammoniac ou un sel d'ammonium ou une amine en présence d'une nitrilase ou d'un polypeptide présentant une activité de nitrilase hydrolysant de manière stéréosélective l'intermédiaire de l'aminonitrile ou de la cyanhydrine dans des conditions permettant la production d'acide carboxylique.
Chaplin Jennifer Ann
Madden Mark
Robertson Dan
Weiner David Paul
Diversa Corporation
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Verenium Corporation
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