C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2459729
The present invention relates to methods for inducing a pro-asthma/pro- inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1.beta., TNF.alpha. or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
L'invention concerne des procédés relatifs à l'établissement d'un état du type pro-asmathique/pro-inflammatoire dans une cellule résidente de tissu, qui consistent à mettre en contact cette cellule avec l'IL-1.beta., le TNF.alpha., ou les deux à la fois. L'invention concerne également des procédés permettant d'identifier les gènes qui régulent les réponses aux anti-inflammatoires, des procédés pour le criblage de médicaments, et des procédés permettant d'identifier les gènes qui ont une corrélation avec différents phénotypes pathologiques du type pro-asmathique/pro-inflammatoire.
Grunstein Michael M.
Hakonarson Hakon
Decode Genetics Ehf.
Gowling Lafleur Henderson Llp
The Children's Hospital Of Philadelphia
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