Methods for producing human ceramide using yeast transformants

Details Methods for producing human ceramide using yeast transformants Methods for producing human ceramide using yeast transformants

C - Chemistry, Metallurgy

12

P

C12P 13/00 (2006.01) C12N 1/19 (2006.01) C12N 15/12 (2006.01) C12N 15/53 (2006.01)

Patent

CA 2689988

The present invention provides a method for producing human ceramide in a yeast cell. The method of the present invention comprises: 1) introducing the sphingoid .DELTA.4-desaturase gene (DES1) by transformation of the yeast cell; 2) abolishing the expression of the yeast sphinganine C4-hydroxylase gene (SUR2) by transformation of the yeast cell; and 3) abolishing the expression of the yeast sphingoid base kinase gene (LCB4) by transformation of the yeast cell.

L'invention concerne un procédé pour produire du céramide humain dans des cellules de levure. Le procédé de production de l'invention comprend les étapes consistant à : 1) introduire un gène de sphingoïde ?4-désaturase (DES1) par transformation de cellule de levure ; 2) désactiver l'expression d'un gène de sphinganine C4-hydroxylase (SUR2) de levure par transformation de cellule de levure ; et désactiver l'expression d'un gène de base sphingoïde kinase (LCB4) de levure par transformation de cellule de levure.

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