Methods for producing immunoglobulins containing protection...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/82 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2208783

The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.

L'invention concerne des immunoglobulines présentant une efficacité thérapeutique contre les agents pathogènes associés aux muqueuses, tels que S. mutans. Ces immunoglobulines contiennent une protéine de protection les protégeant dans le milieu muqueux. L'invention concerne également un procédé grandement amélioré de production d'immunoglobulines dans des végétaux par obtention de la protéine de protection dans la même cellule que les autres constituants des immunoglobulines. Ces constituants sont assemblés avec une efficacité grandement améliorée. Ce procédé permet de réaliser un assemblage et une production hautement efficaces de ces molécules complexes. L'invention concerne également la production d'immunoglobulines contenant des protéines de protection dans une variété de cellules, y compris des cellules végétales, qu'on peut sélectionner en fonction de propriétés complémentaires utiles. Elle concerne enfin l'utilisation des immunoglobulines contenant des protéines de protection en tant qu'anticorps thérapeutiques contre les agents pathogènes associés aux muqueuses et divers autres agents pathogènes.

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