Methods for producing sphingolipids and sphingolipid...

Details Methods for producing sphingolipids and sphingolipid... Methods for producing sphingolipids and sphingolipid...

C - Chemistry, Metallurgy

12

P

C12P 19/44 (2006.01) C12N 9/80 (2006.01) C12P 13/02 (2006.01) C07F 9/10 (2006.01) C07H 15/10 (2006.01)

Patent

CA 2260768

The present invention provides a production method in which a sphingolipid or a sphingolipid derivative having a modified or substituted long chain fatty acid bonded to a sphingoid is specifically synthesized from a sphingolipid or the like, and a sphingolipid or a sphingolipid derivative obtained by the production method. It is characterized in a method for producing a sphingolipid or a sphingolipid derivative, which comprises the step of enzymatically reacting a sphingolipid with an aliphatic carboxylic acid or the like using an enzyme which can specifically hydrolyze an acid-amide bond between a sphingoid and a fatty acid in a sphingolipid or the like to obtain another sphingolipid or sphingolipid derivative having a different fatty acid chain.

L'invention concerne un procédé pour la préparation spécifique de sphingolipides ou de dérivés de sphingolipides, dans lequel le groupe fonctionnel d'acide gras à chaîne longue lié à un sphingoïde est modifié ou substitué. Elle porte aussi sur des sphingolipides ou des dérivés de sphingolipides produits par ledit procédé. Ledit procédé consiste à mettre un sphingolipide en réaction enzymatique avec un acide carboxylique aliphatique ou similaire en présence d'une enzyme hydrolysant spécifiquement la liaison acide-amide entre le sphingoïde et le composant d'acide gras constituant le sphingolipide de sorte qu'un autre sphingolipide ou dérivé de sphingolipide différent de celui d'origine de la chaîne d'acide aliphatique soit produit.

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