Methods for producing synthetic surfaces that mimic collagen...

Details Methods for producing synthetic surfaces that mimic collagen... Methods for producing synthetic surfaces that mimic collagen...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C09D 177/04 (2006.01) C07K 14/78 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2701444

The present invention discloses methods for producing synthetic surfaces that mimic collagen coated surfaces for cell culture comprising: providing a monomer source comprising one or more organic compounds which are capable of polymerization, wherein at least one organic compound is prolinol; creating a plasma of said monomer source; and contacting at least a portion of a surface with the plasma to provide a plasma polymer coated surface. Advantageously, such methods provide an animal-free, synthetic, chemically defined surface that mimics a collagen coated surface for cell culture. Advantageously, such methods not only reduce the cost and/or issues associated with animal-derived collagen but are also amenable to large scale manufacturing.

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