Methods for producing taxane-type diterpenes

Details Methods for producing taxane-type diterpenes Methods for producing taxane-type diterpenes

C - Chemistry, Metallurgy

12

P

C12P 17/02 (2006.01) C12N 5/04 (2006.01) C12P 7/02 (2006.01)

Patent

CA 2241569

The present invention discloses a method for producing a taxane-type diterpene(s) by culturing cells of a taxane-type diterpene-producing plant, comprising one or both of the the following steps (a) and (b) to increase the ratio of those cell clusters suitable in size for diterpene production: (a) at least one operation for removing large cell clusters is conducted with a sieve and/or a filter during preculture of the cells to be supplied to main culture for the production of taxane-type diterpenes or at the time of cell transfer from one preculture to the subsequent preculture; (b) the cells are cultured under strong agitation conditions. The present invention also discloses a method for producing a taxane-type diterpene(s) by culturing cells of a taxane-type diterpene-producing plant, comprising preculturing the cells in a liquid medium under conditions of enriched oxygen supply, supplying the resultant cells to main culture for the production of a taxane-type diterpene(s) and recovering the taxane-type diterpene(s) from the resultant culture. According to the present invention, it is possible to improve the productivity of taxane-type diterpenes in the culture of cells of a taxane-type diterpene-producing plant.

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