Methods for producing temperature-sensitive morbillivirus

Details Methods for producing temperature-sensitive morbillivirus Methods for producing temperature-sensitive morbillivirus

C - Chemistry, Metallurgy

12

N

C12N 15/33 (2006.01) A61K 39/165 (2006.01) A61P 31/12 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/34 (2006.01)

Patent

CA 2399504

It was found that a mutation of an amino acid at a specific position in the P protein of a morbillivirus gives a temperature-sensitivity character to a virus. By introducing this mutation, a virus to which a temperature-sensitivity character has been introduced can be produced. According to this invention, attenuated viruses useful in the preparation of vaccines can be easily produced.

On a découvert qu'une modification d'un acide aminé en une position spécifique de la protéine du Morbilli virus influait sur sa thermosensibilité. On peut dons obtenir un virus rendu sensible à la température en lui transférant cette modification, et produire facilement un virus atténué utilisable pour des vaccins.

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