Methods for producing the anaphase promoting complex

Details Methods for producing the anaphase promoting complex Methods for producing the anaphase promoting complex

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2269099

Methods for identifying novel subunits of the human Anaphase Promoting Complex (APC). The subunits may be identified first in yeast cells or directly in human cells and then be used for producing recombinant human APC. Use of recombinant APC in a screening assay to find substances that inhibit rapidly proliferating cells by interfering with the cells' entry into the subsequent cell cycle.

L'invention concerne des procédés permettant d'identifier de nouvelles sous-unités du complexe stimulant l'anaphase (APC) chez l'humain. Lesdites sous-unités peuvent être identifiées, en premier lieu, dans des cellules de levure ou directement dans des cellules humaines, puis utilisées pour la production d'un APC humain recombiné. L'invention concerne également l'utilisation dudit APC recombiné dans une méthode de criblage pour trouver des substances inhibant des cellules proliférant rapidement en faisant obstacle à l'entrée des cellules dans le cycle cellulaire suivant.

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