Methods for producing transgenic animals

Details Methods for producing transgenic animals Methods for producing transgenic animals

A - Human Necessities

01

K

A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 5/06 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2394600

The present invention relates to methods for producing transgenic animals. Specifically, the methods of the present invention include production of a transgenic animal by transgenic intracytoplasmic sperm injection, retroviral gene transfer, intracytoplasmic nuclear injection, and pronuclear injection. In addition, the present invention also relates to methods for using transgenic animals as models for human disease and diagnosis. In particular, these transgenic animals may be used as models for embryo and fetal development, as models to assess the safety and efficacy of drug therapy and gene therapy, and as models for disease diagnosis. The methods of the present invention are also directed to methods of using transgenic embryonic cells to treat human diseases.

La présente invention concerne des procédés de production d'animaux transgéniques. Particulièrement, ces procédés consistent à produire un animal transgénique par injection intracytoplasmique de sperme transgénique, par transfert de gène rétroviral, par injection intracytoplasmique nucléaire, et par injection pronucléaire. Par ailleurs, cette invention concerne des procédés d'utilisation d'animaux transgéniques comme modèles pour le diagnostic et les maladies humaines. Plus particulièrement, on peut utiliser ces animaux transgéniques comme modèles pour les développements embryonnaire et foetal, comme modèles pour établir l'innocuité et l'efficacité de thérapies médicamenteuse et génique, et comme modèles pour le diagnostic de maladies. De plus, cette invention concerne des procédés d'utilisation de cellules embryonnaires transgéniques pour traiter des maladies humaines.

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