Methods for producing transgenic non-human animals harboring...

Details Methods for producing transgenic non-human animals harboring... Methods for producing transgenic non-human animals harboring...

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2135313

2135313 9400569 PCTABS00030 The present invention provides methods and compositions for transferring large transgene polynucleotides and unlinked selectable marker polynucleotides into eukaryotic cells by a novel method designated co-lipofection. The methods and compositions of the invention are used to produce novel transgenic non-human animals harboring large transgenes, such as a transgene comprising a human APP gene or human immunoglobulin gene.

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