Methods for promoting neurite outgrowth and survival of...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01)

Patent

CA 2628451

The present invention relates generally to methods for promoting regeneration, outgrowth and survival of dopaminergic neurons comprising contacting said dopaminergic neurons with an effective amount of a composition comprising an Sp35 antagonist. Additionally, the invention is related generally to methods of treating various diseases, disorders or injuries associated with dopaminergic neuronal degeneration or death by administration of an Sp35 antagonist.

En règle générale, procédés favorisant la régénération, la croissance et la survie de neurones dopaminergiques par contact entre ces neurones et une quantité efficace de composition qui comprend un antagoniste vis-à-vis de Sp 35. Par ailleurs, l'invention concerne en règle générale des procédés de traitement de maladies, troubles ou lésions associés à la dégénérescence ou à la mort des neurones dopaminergiques, par administration d'antagoniste vis-à-vis de Sp35.

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