Methods for promoting production of myelin by schwann cells

Details Methods for promoting production of myelin by schwann cells Methods for promoting production of myelin by schwann cells

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 38/19 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2401716

A method for promoting the expression of myelin or Protein Zero in Schwann cells using Zcyto7 or IL-17. Zcyto7 or IL-17 are further used to promote myelination of the peripheral nervous system. This is particularly useful in treating diseases dymyelinating diseases such as diabetic neuropathy, Guillain- Barre' Syndrome, chronic demyelinating disease, acute demyelinating polyneuropathy and human immunodeficiency viral demyelinating neuropathy or demyelination caused by trauma.

La présente invention concerne un procédé permettant de favoriser l'expression de la myéline ou de la protéine zéro dans les cellules de Schwann, au moyen de Zcyto7 ou IL-17. Zcyto7 ou IL-17 sont également utilisés pour favoriser la myélinisation du système nerveux périphérique. Ceci s'avère particulièrement utile pour le traitement de maladies de démyélinisation telles que la neuropathie diabétique, le syndrome de Guillain-Barre, la maladie de démyélinisation chronique, la polyneuropathie à démyélinisation aiguë et la neuropathie à démyélinisation du virus d'immunodéficience humaine ou la démyélinisation causée par un traumatisme.

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