C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/805 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C08J 3/02 (2006.01) C08L 71/02 (2006.01) C07K 17/08 (2006.01)
Patent
CA 2455974
The present invention employs a dissolved activated polyethylene glycol (aPEG) or related molecule that has been passed through a filtration means for the substantial reduction of bioburden or endotoxin levels in the aPEG solution. The resulting filtered aPEG solution can be used for the preparation of a PEGylated hemoglobin solution containing substantially reduced levels of bioburden or endotoxin.
La présente invention concerne l'utilisation d'une solution de polyéthylène-glycol activée (aPEG), ou d'une molécule s'y rapportant. Cette solution ou cette molécule ont subi un filtrage visant à réduire de façon sensible leurs niveaux de biocontamination ou d'endotoxines. La solution de polyéthylène-glycol activée filtrée qui en résulte convient pour la préparation d'une solution d'hémoglobine traitée à charge réduite en biocontaminants ou en endotoxines.
Stacey Cyrus John
Talarico Todd Lewis
Apex Bioscience Inc.
Smart & Biggar
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