Methods for purifying highly anionic proteins

Details Methods for purifying highly anionic proteins Methods for purifying highly anionic proteins

C - Chemistry, Metallurgy

07

K

C07K 1/18 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2404155

The present invention provides a process for isolating and purifying highly anionic target proteins, for example, sulfated proteins. Sulfated proteins have five (5) or more, sulfations. In a preferred embodiment, the sulfated protein has six (6) sulfations, e.g., six sulfations on N-terminal tyrosine residues, as embodied in PSGL-1 (P-selectin glycoprotein ligand).

La présente invention concerne un processus d'isolation et de purification de protéines cibles hautement anioniques, telles que des protéines sulfatées. Ces protéines sulfatées comprennent au moins cinq (5) sulfatations. Dans un mode de réalisation préféré, la protéine sulfatée comprend six (6) sulfatations, par exemple sur les résidus de tyrosines N-terminales, comme on le voit dans le ligand PSGL-1 (ligand de glycoprotéine P-sélectine).

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