Methods for purifying radiolabelled compounds

Details Methods for purifying radiolabelled compounds Methods for purifying radiolabelled compounds

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 51/00 (2006.01) C07C 51/42 (2006.01) C07C 209/84 (2006.01) C07C 231/24 (2006.01) C07C 277/06 (2006.01) C07K 1/14 (2006.01)

Patent

CA 2502358

One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabelled compound precursor with a radiolabel delivering compound to give a radiolabelled compound, wherein the fluoroalkyl tin moiety is replaced by a radiolabel; and c) eluting the radiolabelled compound from the fluorous polymer.

Dans un mode de réalisation, la présente invention a trait à un procédé de purification de composés radiomarqués comprenant : a) le chargement sur un polymère fluoré d'un précurseur de composé radiomarqué comprenant un groupe fonctionnel d'étain fluoroalkyle ; b) la réaction du précurseur de composé radiomarqué avec un composé de délivrance de radiomarquage pour obtenir un composé radiomarqué, dans lequel une radiomarque se substitue au groupe fonctionnel d'étain fluoroalkyle ; et c) l'élution du composé radiomarqué du polymère fluoré.

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