Methods for radiolabelling macromolecules

Details Methods for radiolabelling macromolecules Methods for radiolabelling macromolecules

A - Human Necessities

61

K

A61K 51/06 (2006.01) A61K 49/12 (2006.01) A61K 49/14 (2006.01) A61K 49/16 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2721836

The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.

Linvention concerne un procédé de préparation dune macromolécule radiomarquée. Ce procédé consiste à mettre en contact une macromolécule avec un composite de nanoparticules encapsulées dans du carbone, contenant un noyau particulaire radioactif, dans un milieu aqueux présentant un pH sélectionné pour favoriser des forces dattraction courte portée entre les nanoparticules et la macromolécule, par atténuation des forces de répulsion électrostatiques.

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