A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2520875
The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. The present invention provides a method of predicting the relationship among polymer attachment sites, sizes and specific activities to generate proteins with altered properties. It is an object of the invention to provide a computational method of designing polymer attachment sites and Positions. It is a further object of the invention to provide a computational method of optimizing polymer attachment to a molecule. It is another object To produce optimized molecules with polymer attachements.
La présente invention concerne l'utilisation d'une technologie de simulation pour optimiser rationnellement la localisation et les tailles de fractions polymères attachées destinées à modifier des protéines thérapeutiques et les protéines générées par ce procédé.
Desjarlais John Rudolph
Zalevsky Jonathan
Smart & Biggar
Xencor Inc.
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