Methods for reducing chronic stress in mammals

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 31/00 (2006.01) A61P 5/02 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2433165

This invention relates to methods for reducing chronic stress in mammals by administering a sensory regimen which reduces or down-regulates the activity of the HPA axis. The activity of the HPA axis of the mammal may be downregulated by at least one of the following methods: (1) reducing the amount of total daily adrenocortical hormone; (2) reducing adrenocortical hormone at any time point in the period from about 4 to about 8 hours following morning waking; (3) reducing the total daily adrenocortical hormone minus the integrative measure of morning peak adrenocortical hormone. Generally, the sensory regimen is selected from the group consisting of auditory stimuli, visual stimuli, tactile stimuli, gustatory stimuli, olfactory stimuli and combinations thereof.

L'invention concerne des procédés visant à réduire le stress chronique chez le mammifère par l'administration d'un régime organoleptique qui réduit ou régule négativement l'activité de l'axe hypothalamo-hypophyso-surrénalien. L'activité de l'axe hypothalamo-hypophyso-surrénalien peut être régulé négativement selon l'un des procédés suivants : 1) la réduction de la quantité totale quotidienne d'hormones cortico-surrénales ; 2) la réduction d'hormones cortico-surrénales à un moment quelconque au cours d'une période comprise entre 4 et 8 heures environ suivant le réveil ; 3) la réduction de la quantité totale quotidienne d'hormones cortico-surrénales moins la mesure d'intégration des hormones cortico-surrénales du pic matinal. En règle générale, le régime organoleptique est sélectionné dans le groupe constitué par les stimulations auditives, les stimulations visuelles, les stimulations tactiles, les stimulations gustatives, les stimulations olfactives et des combinaisons de ces dernières.

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