Methods for reducing fat by administration of adiponectin

Details Methods for reducing fat by administration of adiponectin Methods for reducing fat by administration of adiponectin

A - Human Necessities

61

K

A61K 38/22 (2006.01) A61K 38/17 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2440144

The stromal cells that support blood cell production within bone marrow are pre-adipocytes and functional interactions with marrow fat cells have long been suspected. Adiponectin was recently isolated as an adipocyte product and shown to have structural similarities to Clq as well as members of the TNF superfamily. It suppresses myeloid differentiation in short term bone marrow cultures and also inhibits macrophage functions.

Selon l'invention, les cellules stromales qui supportent la production de globules sanguins dans la moelle épinière sont des pré-adipocytes et on a longtemps suspecté des interactions fonctionnelles avec les cellules remplies de graisse de la moelle. L'adiponectine a été récemment isolée en tant que produit d'adipocyte et on a montré qu'elle présente des similarités de structure avec Clq ainsi qu'avec des membres de la superfamille des TNF. Elle permet de supprimer la différentiation myéloïde dans des cultures de moelle osseuse de courte durée et aussi d'inhiber des fonctions de macrophages.

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