Methods for reducing hyperacute rejection of xenografts

Details Methods for reducing hyperacute rejection of xenografts Methods for reducing hyperacute rejection of xenografts

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2192660

A method for reducing xenograft rejection is provided wherein a vector directing the expression of a protein having glycosyltransferase activity is introduced into xenogeneic cells. Cells so prepared exhibit a substantial reduction in their binding to naturally occuring preformed human antibodies and are thus protected from hyperacute rejection.

Procédé permettant de réduire le rejet des hétérogreffes selon lequel on introduit dans des cellules xénogéniques un vecteur qui dirige l'expression d'une protéine possédant une activité glycosyltransférase. Les cellules préparées de la sorte présentent une réduction substantielle de leur fixation à des anticorps humain préformés apparaissant naturellement et sont donc protégées contre le rejet suraigu.

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