Methods for reducing intraocular pressure using a3-adenosine...

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A61P 27/06 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/138 (2006.01) A61K 31/435 (2006.01) A61K 31/4418 (2006.01) A61K 31/4422 (2006.01) A61K 31/4425 (2006.01) A61K 31/455 (2006.01) A61K 31/498 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5415 (2006.01)

Patent

CA 2337499

A method for decreasing intraocular pressure by administering an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen. These agents, by inhibiting influx or promoting efflux of aqueous humor, can be used to treat glaucoma.

Un procédé permettant de réduire la pression intra-oculaire consiste à administrer un antagoniste du récepteur d'adénosine du sous-type A¿3?, un antagoniste de calmoduline ou un anti-oestrogène tel que du tamoxifène. Ces agents, du fait qu'ils inhibent l'entrée ou favorisent la sortie de l'humeur aqueuse peuvent être utilisés pour traiter le glaucome.

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