Methods for reducing or preventing liquid-liquid phase...

Details Methods for reducing or preventing liquid-liquid phase... Methods for reducing or preventing liquid-liquid phase...

C - Chemistry, Metallurgy

07

K

C07K 1/14 (2006.01) C07K 1/02 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2655072

Methods of formulating proteins at high concentrations in protein solutions, wherein the protein solutions lack or have reduced liquid-liquid phase separation are described. Such protein solutions are substantially clear and substantially homogenous. Additionally, methods of concentrating and purifying proteins using liquid-liquid phase separation are provided.

La présente invention concerne des procédés de formulation de protéines à hautes concentrations dans des solutions protéiques, les solutions protéiques étant exemptes d'une séparation ou présentant une séparation réduite de la phase liquide-liquide. De telles solutions protéiques sont sensiblement limpides et homogènes. L'invention concerne en outre des procédés permettant de concentrer et de purifier des protéines au moyen d'une séparation de phase liquide-liquide.

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