Methods for refolding polypeptides

Details Methods for refolding polypeptides Methods for refolding polypeptides

C - Chemistry, Metallurgy

07

K

C07K 1/113 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2584137

The invention relates to subjecting column isolated preparations of polypeptides with a reduction/oxidation reagent and a chaotropic agent and isolating the refolded active protein produced from said contacting. The active proteins can be high molecular weight proteins including Fc domain containing polypeptides or fragments.

Selon la méthode de l'invention, des préparations de polypeptides isolées dans une colonne sont placées au contact d'un réactif d'oxydo-réduction et d'un agent chaotropique, et la protéine active repliée ainsi obtenue est isolée. Les protéines actives peuvent être des protéines de poids moléculaire élevé dont des polypeptides comprenant le domaine Fc ou leurs fragments.

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