Methods for regulating a cell-mediated immune response by...

Details Methods for regulating a cell-mediated immune response by... Methods for regulating a cell-mediated immune response by...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2411962

The invention provides methods for regulating cell-mediated immune responses, immune system diseases and allograft transplant rejection by interfering with the interaction of at least three different cell surface molecules with their natural ligands. A first cellular interaction is mediated by CD28/B7/CTLA4, a second interaction is mediated by CD40/CD154, and a third interaction is mediated by LFA-1 interaction with its ligands. Regulation of a cell-mediated immune response affects immune system diseases such as those associated with allograft transplantation.

L'invention concerne des procédés de régulation de réponses immunitaires à médiation cellulaire, de maladies du système immunitaire et du rejet des allogreffes au moyen d'une intervention au niveau de l'interaction d'au moins trois molécules différentes de surface de cellules avec leurs ligants naturels. Une première interaction cellulaire est induite par CD28/B7/CTLA4, une deuxième interaction est induite par CD40/CD154, et une troisième interaction est induite par une interaction de l'antigène LFA-1 avec ses ligands. La régulation de la réponse immunitaire à médiation cellulaire influence les maladies du système immunitaire telles que celles qui sont associées à une allogreffe.

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