Methods for regulating bacteria

A - Human Necessities – 61 – K

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A61K 39/108 (2006.01) A61K 31/00 (2006.01) A61K 31/122 (2006.01) A61K 31/341 (2006.01)

Patent

CA 2443287

Bacteria lacking the ability to secrete autoinducer-2 may nonetheless be regulated by contacting the bacteria with an amount of an autoinducer-2 effector that is sufficient to regulate the bacterium. Pseudomonas aeruginosa, a bacterium that colonizes the lungs of cystic fibrosis patients with often devastating effects on health, is a preferred target for regulation.

Les bactéries n'ayant pas la capacité de sécréter l'auto-inducteur-2, peuvent, néanmoins, être régulées par mise au contact avec des bactéries ayant une quantité de récepteur d'auto-inducteur-2 suffisante pour réguler celles-ci. Pseudomonas aeruginosa, une bactérie, qui colonise les poumons des patients atteints de mucoviscidose, avec des effets dévastateurs sur la santé, est une cible privilégiée de la régulation.

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