A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/00 (2006.01) A61K 33/40 (2006.01) A61K 35/12 (2006.01) A61K 38/28 (2006.01) A61N 5/02 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C12N 5/00 (2006.01) C12N 13/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2463442
The invention is based in part on the discovery that the expression of co- stimulatory molecules such as B7.1, B7.2 or CD40 can be regulated using reactive oxygen species (ROS). Thus, the invention relates to methods of regulating co-stimulatory molecules by modulating reactive oxygen. The methods and products are useful, for example, for modulating antigen specific immune responses, treating disease, and for modulating cell growth.
L'invention est basée en partie sur la découverte que l'expression de molécules co-stimulantes telles que B7.1, B7.2 ou CD40 peut être régulée au moyen d'espèces à oxygène réactif. Ainsi, l'invention se rapporte à des procédés de régulation de molécules co-stimulantes consistant à moduler l'oxygène réactif. Les procédés et les produits sont utiles, par exemple, afin de moduler les réponses immunes spécifiques d'antigène, de traiter des maladies et de moduler la croissance cellulaire.
Camley Robert E.
Celinski Zbigniew
Christiansen Thomas
Ill C. Richard
Newell Evan
Smart & Biggar
The Regents Of The University Of Colorado
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