Methods for regulating inflammatory mediators and peptides...

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01)

Patent

CA 2645019

The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from the vesicles or granules in the inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. MANS peptide and active fragments thereof are useful in such methods.

L'invention concerne des méthodes de modulation des processus sécrétoires cellulaires. Plus particulièrement, l'invention concerne la modulation ou la réduction de la libération de médiateurs inflammatoires à partir de cellules inflammatoires, par inhibition du mécanisme associé à la libération de médiateurs inflammatoires à partir des vésicules ou granules des cellules inflammatoires. L'invention concerne à cet égard un mécanisme de signalisation intracellulaire qui met en évidence plusieurs nouvelles cibles intracellulaires pour une intervention pharmacologique dans le cas de troubles impliquant une sécrétion de médiateurs inflammatoires par les vésicules des cellules inflammatoires. Le peptide MANS et des fragments actifs de celui-ci sont utiles dans ces méthodes.

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