A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7105 (2006.01) C12N 15/113 (2010.01) G06F 19/10 (2011.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) G01N 33/574 (2006.01) C07H 21/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2695184
Methods for restoring a desired pattern of DNA methylation, inducing re- expression of methylation-silenced tumor suppressor genes (TSGs), and/or inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof by administering an effective amount of one or more miR-29s sufficient to target one or more of DNMT3A and DNMT3B are disclosed.
L'invention concerne des procédés permettant de rétablir un motif souhaité de méthylation d'ADN, comprenant la réexpression de gènes suppresseurs de tumeur inactivés par méthylation (TSG), et/ou l'inhibition de la tumorigénicité à la fois in vitro et in vivo chez un sujet qui en a besoin par administration d'une quantité efficace d'un ou plusieurs mir-29 suffisants pour cibler un ou plusieurs DNMT3A et DNMT3B.
Croce Carlo M.
Fabbri Muller
Ridout & Maybee Llp
The Ohio State University Research Foundation
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