C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/52 (2006.01) A61K 31/55 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2169466
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be futher tested for the ability to modulate the standard estrogen response, as well.
Nouveaux procédés d'analyse destinés à identifier des composés qui peuvent avoir des propriétés à la fois agonistes et antagonistes des oestrogènes. En particulier, ladite analyse utilise des cellules comprenant des promoteurs ayant un site AP1 lié à un gène rapporteur. Des composés capables d'induire ou de bloquer l'expression du gène rapporteur peuvent donc être identifiés. Lesdits composés peuvent en outre être testés également en vue de leur capacité à moduler la réponse oestrogène standard.
Kushner Peter
Webb Paul
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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