Methods for screening compound libraries

Details Methods for screening compound libraries Methods for screening compound libraries

G - Physics

01

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G01N 33/53 (2006.01) C12Q 1/68 (2006.01) G01N 33/538 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) H01J 49/04 (2006.01) G01N 30/46 (2006.01) G01N 30/62 (2006.01) G01N 30/72 (2006.01)

Patent

CA 2240325

Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. Methods are also disclosed which permit a compound library to be rapidly screened to determine if any members of the library have a higher affinity for the target receptor relative to a pre-selected indicator compound.

Méthodes de criblage de banques de constituants au moyen de la chromatographie frontale, en combinaison avec la spectrométrie de masse, afin d'identifier et de classer les éléments d'une banque qui sont liés à un récepteur cible. On décrit de plus des méthodes permettant de cribler rapidement une banque de constituants afin de déterminer si certains de ses éléments ont une plus grande affinité avec le récepteur cible par rapport à un constituant-témoin présélectionné.

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