Methods for screening compounds active on neurons

G - Physics – 01 – N

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G01N 33/53 (2006.01) C12Q 1/02 (2006.01) C40B 30/06 (2006.01) G01N 33/50 (2006.01) C12N 5/0793 (2010.01)

Patent

CA 2390671

The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.

La présente invention concerne des compositions et des procédés pour cribler et/ou identifier les composants manifestant une action biologique sur les neurones. L'invention concerne aussi l'isolation et la culture de neurones, des procédés pour créer des conditions pathologiques desdits neurones isolés ainsi que des kits pour mettre en oeuvre ces procédés. L'invention peut être utilisée en recherche expérimentale, dans la découverte de médicaments, le développement de médicaments et similaire. Elle peut notamment être utilisée pour identifier et/ou caractériser et/ou améliorer les composants agissant sur les neurones; elle peut être utilisée pour traiter des troubles du système nerveux.

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