C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/135 (2006.01) A61K 31/35 (2006.01) A61K 31/52 (2006.01) A61K 31/55 (2006.01) C07K 14/72 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2215922
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters having an AP1 site linked to a reporter gene. Compounds capable of inducing or blocking expression of the reporter gene can thus be identified. The compounds may be further tested for the ability to modulate the standard estrogen response, as well.
La présente invention porte sur de nouvelles méthodes d'analyse pour l'identification de composés qui pourraient agir à la fois comme des agonistes et des antagonistes de l'oestrogène. En particulier, les analyses utilisent des cellules contenant des promoteurs ayant un site AP1 liés à un gène marqueur. Les composés capables de provoquer ou d'inhiber l'expression du gène marqueur peuvent ainsi être identifiés. Il est également possible de déterminer si ces composés sont capables de moduler la réponse habituelle à l'oestrogène.
Hunt C. Anthony
Kushner Peter
Lopez Gabriella
Webb Paul
Williard Renee
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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