Methods for screening drugs to predict tardive dyskinesia

Details Methods for screening drugs to predict tardive dyskinesia Methods for screening drugs to predict tardive dyskinesia

G - Physics

01

N

G01N 33/00 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2305732

The present invention provides screening methods for identifying compounds which induce tardive dyskinesia (TD) when administered to an animal. In particular, the methods involve assaying for intermediates and end product of reactions associated with candidate compound mediated reduction of reducible substrates. Also provided are high-throughput screening methods for determining whether compounds induce TD when administered to an animal. Further, provided are methods for treating psychoses comprising testing antipsychotic drugs to identify those which will not induce TD when administered to an animal and administering one or more such drugs to a patient in need thereof.

L'invention concerne des techniques de criblage permettant d'identifier les composés qui induisent une dyskinésie tardive (DT) quand ils sont administrés à un animal. Ces techniques consistent notamment à analyser les produits intermédiaires et les produits terminaux de réactions associées à la réduction, provoquée par le composé candidat, de substrats pouvant être réduits. L'invention concerne également des techniques de criblage à haut rendement, qui permettent de déterminer si des composés induisent une DT quand ils sont administrés à un animal. Elle concerne aussi des méthodes qui permettent de traiter les psychoses, selon lesquelles on teste des neuroleptiques afin d'identifier ceux qui ne provoquent pas de DT quand ils sont administrés à un animal, puis on administre un ou plusieurs de ces neuroleptiques à un patient qui en a besoin.

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