Methods for selective targeting

Details Methods for selective targeting Methods for selective targeting

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2405715

A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10-7 to 10-10 M. Additionally claimed are the ligands identified according to the method.

L'invention concerne une méthode de ciblage sélectif consistant à mettre en contact une librairie de ligands, notamment une librairie de peptides, avec une anti-cible pour permettre aux ligands de se lier à l'anti-cible, séparer les ligands exempts de liaison des ligands liés à l'anti-cible, mettre en contact les ligands anti-cibles exempts de liaison avec une cible permettant aux ligands non liés de se lier à la cible pour former un complexe de ligands liés à la cible, séparer ledit complexe des ligands qui ne se lient pas à la cible, et identifier les ligands liés à la cible sur le complexe de ligands liés à la cible, ces mêmes ligands présentant un K¿D? compris entre 10?-7¿ et 10?-10¿ M. En outre, cette invention concerne les ligands identifiés selon cette méthode.

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