C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/14 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 5/02 (2006.01) C12N 5/18 (2006.01) C12Q 1/02 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12N 11/00 (2006.01)
Patent
CA 2164226
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
Ces procédés induisent la prolifération d'une population de lymphocytes T par activation de ladite population de lymphocytes T et stimulation d'une molécule accessoire sur la surface des lymphocytes T au moyen d'un ligand liant la molécule accessoire. La prolifération des limphocytes T se produit en l'absence de facteurs de croissance exogènes ou de cellules accessoires. L'activation des lymphocytes T est obtenue par stimulation du complexe récepteur de lymphocytes T (TCR)/CD3 ou de la protéine de surface CD2. Pour induire la prolifération des lymphocytes T d'une population activée, une molécule accessoire sur la surface des cellules T telle que la CD28, est stimulée par un ligand qui lie la molécule accessoire. La population de lymphocytes T développée par ces procédés peut faire l'objet d'une transduction génétique et d'une utilisation en immunothérapie. Elle peut également être utiisée pour des procédés de diagnostics.
Freeman Gordon J.
Gray Gary S.
June Carl H.
Nabel Gary J.
Rennert Paul D.
Dana-Farber Cancer Institute
Genetics Institute Llc
Gowling Lafleur Henderson Llp
Repligen Corporation
The Regents Of The University Of Michigan
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