Methods for similarity searching of chemical reactions

G - Physics – 06 – F

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G06F 19/00 (2011.01) C40B 30/04 (2006.01)

Patent

CA 2693244

A computer-based method for identifying at least one pair of similar chemical reactions between a plurality of reactions each related to preparation of at least one product from at least one reagent may include generating for each reaction a structural representation involving dynamic and conventional bonds and, based on the this structural representation, generating for each reaction a set of fragment descriptors of a predetermined length comprising the dynamical bonds and a corresponding descriptor vector. The method may further include calculating similarity indices between descriptor vectors of the plurality of reactions and comparing the similarity indices to identify at least one pair of similar reactions.

L'invention concerne un procédé informatisé servant à identifier au moins une paire de réactions chimiques analogues parmi une pluralité de réactions, chacune concernant la préparation d'au moins un produit à partir d'au moins un réactif, lequel procédé peut consister à générer pour chaque réaction une représentation de structure comprenant les liaisons dynamiques et classiques et, sur la base de cette représentation de structure, générer pour chaque réaction un ensemble de descripteurs de fragments ayant une longueur prédéterminée comprenant les liaisons dynamiques et un vecteur descripteur correspondant. Le procédé peut en outre consister à calculer des indices d'analogie entre des vecteurs descripteurs de la pluralité de réactions et comparer les indices d'analogie pour identifier au moins une paire de réactions analogues.

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