Methods for site-specific pegylation

Details Methods for site-specific pegylation Methods for site-specific pegylation

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) C08G 65/334 (2006.01) C07K 5/00 (2006.01)

Patent

CA 2653717

The present invention relates to methods for the chemo-selective pegylation of the cysteine residue having unoxidized sulfhydryl side-chain and free .alpha.-amino group in proteins, peptides and other molecules. Similar methods are provided for the chemo- selective pegylation of the homocysteine, selenocysteine, penicillamine, and N-methyl- cysteine residues.

La présente invention concerne des méthodes de pégylation chimiosélective du résidu cystéine comportant une chaîne latérale sulfhydryle non oxydée et un groupement .alpha.-amino libre dans les protéines, les peptides ou d'autres molécules. L'invention concerne également des méthodes similaires pour la pégylation chimiosélective des résidus homocystéine, sélénocystéine, pénicillamine et N-méthylcystéine.

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