Methods for specifically inhibiting histone deacetylase-7 and 8

Details Methods for specifically inhibiting histone deacetylase-7 and 8 Methods for specifically inhibiting histone deacetylase-7 and 8

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/167 (2006.01) A61K 31/4015 (2006.01) A61K 31/4035 (2006.01) A61K 31/4184 (2006.01) A61K 31/428 (2006.01) A61K 31/505 (2006.01) A61K 31/5377 (2006.01) A61K 31/7088 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2490579

This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-7 and HDAC-8 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.

L'invention se rapporte à l'inhibition de l'expression de l'histone déacétylase (HDAC) et de l'activité enzymatique. L'invention concerne des procédés et des réacteurs d'inhibition de HDAC-7 et HDAC-8 par inhibition de l'expression au niveau de l'acide nucléique et par inhibition de l'activité enzymatique au niveau protéique.

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