Methods for stabilizing benzimidazole-based compounds

Details Methods for stabilizing benzimidazole-based compounds Methods for stabilizing benzimidazole-based compounds

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61K 9/20 (2006.01) A61K 47/02 (2006.01) A61K 47/32 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2387746

The invention provides a method for stabilizing peroral solid preparations containing benzimidazole compounds or physiologically acceptable salts thereof. Specifically, a method for stabilizing benzimidazole compounds or physiologically acceptable salts thereof, characterized by blending the compounds or the salts with (1) crospovidone and, if necessary, (2) sodium hydroxide and/or potassium hydroxide.

L'invention concerne un procédé de stabilisation de préparations solides perorales contenant des composés benzimidazoles ou des sels de ceux-ci, acceptables sur le plan physiologique. L'invention concerne notamment un procédé de stabilisation de composés benzimidazoles, ou de sels de ceux-ci, acceptables sur le plan physiologique, ce procédé consistant à mélanger les composés ou les sels avec (1) de la crospovidone, et le cas échéant, avec (2) de l'hydroxyde de sodium et/ou de potassium.

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